top of page
This site was designed with the
.com
website builder. Create your website today.Start Now

研究團隊開發一種同時可針對活性氧物質與穀胱苷肽產生應答之奈米藥物。在癌細胞中，奈米藥物可發生氧化或還原作用而釋放藥物；而正常細胞因活性氧物質或穀胱苷肽濃度低而無法釋放藥物。研究結果顯示，該奈米藥物能針對大腸直腸癌細胞、肺癌上皮細胞、胃癌等細胞進行毒殺，而對於正常細胞則無明顯毒性。由動物實驗亦證實能有效抑制大腸直腸癌腫瘤生長，並減少對正常組織之傷害。相較於文獻所見之奈米藥物，本研究提供一可選擇性毒殺癌細胞之奈米藥物結構設計概念，廣泛應用於多種癌症治療上。

近年研究成果:

  1. T.A. Debele, L.Y. Yu, C.S. Yang, Y.A. Shen, C.L. Lo*. pH- and GSH-sensitive hyaluronic acid-MP conjugate micelles for intracellular delivery of doxorubicin to colon cancer cells and cancer stem cells. Biomacromolecules 2018, 19, 3725-3737. (IF: 5.736; Ranking: 6/87)

  2. Y.T. Chiang, S.Y. Lyu, Y.H. Wen, C.L. Lo*. Preparation and characterization of electrostatically crosslinked polymer-liposomes in anticancer therapy. Int. J. Mol. Sci. 2018, 19, No. 1615. (IF: 3.687; Ranking: 90/292)

  3. T.A. Debele, K.Y. Lee, N.Y. Hsu, Y.T. Chiang, L.Y. Yu, Y.A. Shen, C.L. Lo*. A pH sensitive polymeric micelle for co-delivery of doxorubicin and a-TOS for colon cancer therapy. J. Mater. Chem. B. 2017, 5, 5870-5880. ( IF: 4.776; Ranking: 8/33)

  4. Y.H. Wen, T.Y. Lee, P.C. Fu, C.L. Lo*, Y.T. Chiang*. Multifunctional polymer nanoparticles for dual drug release and cancer cell targeting. Polymers 2017, 9, 213. (IF: 2.935; Ranking: 19/87)

  5. L.Y. Yu, G.M. Su, C.K. Chen, Y.T. Chiang, C.L. Lo*. Specific cancer cytosolic drug delivery triggered by reactive oxygen species-responsive micelles. Biomacromolecules 2016, 17, 3040-3047. (IF: 5.736; Ranking: 6/87)

  6. K.Y. Lee, Y.T. Chiang, N.Y. Hsu, C.Y. Yang, C.L. Lo*, C.A. Ku. Vitamin E containing polymer micelles for reducing normal cell cytotoxicity and enhancing chemotherapy efficacy. Acta Biomaterialia 2015, 24, 286-296. (IF: 6.383; Ranking: 3/33)

  7. K.Y. Lee, Y.T. Chiu, C.L. Lo*. Preparation and characterization of potential doxorubicin-loaded mixed micelles formed from vitamin E containing graft copolymers and PEG-b-PLA diblock copolymers. RSC Advances 2015, 5, 83825-83836. (IF: 2.936; Ranking: 71/170)

  8. Y.T. Chiang, Y.W. Yen, C.L. Lo*. Reactive oxygen species and glutathione dual redox-responsive micelles for selective cytotoxicity of cancer. Biomaterials 2015, 61, 150-161. (IF: 8.806; Ranking: 1/33)

  9. Y.T. Chiang, C.L. Lo*. pH-Responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy. Biomaterials 2014, 35, 5414-5424. (IF: 8.806; Ranking: 1/33)

  10. Y.T. Chiang, Y.T. Cheng, C.Y. Lu, Y.W. Yen, L.Y. Yu, K.S. Yu, S.Y. Lyu, C.Y. Yang, C.L. Lo*. Polymer-liposome complexes with a functional hydrogen-bond cross-linker for preventing protein adsorption and improving tumor accumulation. Chem. Mater. 2013, 25, 4364-4372. (IF: 9.407; Ranking: 15/271)

  11. C.L. Lo*, M.H. Chou, P.L. Lu, I.W. Lo, Y.T. Chiang, S.Y. Hung, C.Y. Yang, S.Y. Lin, S.P. Wey, J.M. Lo, G.H. Hsiue*. The effect of PEG-5K grafting level and particle size on tumor accumulation and cellular uptake. Int. J. Pharmaceut. 2013, 456, 424-431. (IF: 3.650; Ranking: 43/253)

  12. S.Y. Lin, W.Y. Zhao, H.C. Tsai, W.H. Hsu, C.L. Lo*, G.H. Hsiue*. Sterically polymer-based liposomal complexes with dual-shell structure for enhancing the siRNA delivery. Biomacromolecules 2012, 13, 664-675. (IF: 5.736; Ranking: 6/87)

  13. P.L. Lu, Y.C. Chen, T.W. Ou, H.H. Chen, H.C. Tsai, C.J. Wen, C.L. Lo*, S.P. Wey, K.J. Lin, T.C. Yen*, G.H. Hsiue*. Multifunctional hollow nanoparticles based on graft-diblock copolymers for doxorubicin delivery. Biomaterials 2011, 32, 2213- 2221. (IF: 8.806; Ranking: 1/33)

  14. H.C. Tsai, W.H. Chang, C.L. Lo, C.H. Tsai, C.H. Chang, T.W. Ou, T.C. Yen and G.H. Hsiue* (2010). “Graft and diblock copolymer multifunctional micelles for cancer chemotherapy and imaging”, Biomaterials, 31, 2293-2301. (equal first author) (IF: 8.806; Ranking: 1/33)

 

bottom of page